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| c. 4000 BC |
| | Oxen are the first draught animals, in use at this time in the Middle East and in Europe | |
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| c. 2000 BC |
| | Trade is carried on from Crete round the Mediterranean as far west as Sicily and in the east down to Egypt | |
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| 335 BC |
| | Before departing for the east, Alexander destroys Thebes and enslaves the Thebans for rebelling against the League of Corinth | |
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| c. 250 BC |
| | The Chinese develop the crossbow, many centuries before its use in Europe | |
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| -86 BC |
| | Sulla, campaigning to the east, besieges Athens and then allows his army to loot the city | |
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| c. 250 |
| | The Goths split into two major groups, the Visigoths northwest of the Black Sea and the Ostrogoths further east | |
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| 1095 |
| | Pope Urban II preaches the first crusade, urging the Christians of Europe to march east to recover Jerusalem from the Muslims | |
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| 1147 |
| | The second crusade is led east by two kings, Louis VII of France and Conrad III of Germany | |
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| 1157 |
| | A Russian prince, Andrei Bogolyubski, makes his capital east of Moscow at Vladimir, where he builds a cathedral and several churches | |
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| 1190 |
| | A year after succeeding to the throne of England, Richard I sets off east as one of the leaders of the third crusade | |
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